SAB5100002

Imprint^® ChIP-Validated Monoclonal Anti-p53 (DO-7) antibody produced in mouse

clone DO-7, purified immunoglobulin, isotype IgG2b

• Synonym(s): Imprint^® Monocolonal Anti-p53 antibody produced in mouse, Anti-LFS1, Anti-P53, Anti-TP53, Anti-TRP53, Anti-tumor protein p53
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: DO-7, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): ChIP: suitable; western blot: suitable
• isotype: IgG2b
• UniProt accession no.: P04637
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... TP53(7157)

Description

General description

The tumor protein p53 (TP53) gene is a tumor suppressor gene that encodes p53 protein. This protein is a nuclear transcription factor. It is made up of three functional domains, such as the NH₂-terminal acidic transactivation domain, DNA-binding domain and a COOH-terminal oligomerization domain. p53 protein is located in the nucleus and directly binds to the DNA. The TP53 gene is mapped on the human chromosome at 17p13.1.

Biochem/physiol Actions

p53 protein plays a very important role in suppressing cancer by promoting cell-cycle-arrest or apoptosis as a feedback mechanism to DNA damage. It also plays a role in autophagy, regulating metabolism and oxidative status of the cell. p53 protein is also a part of angiogenesis, senescence, cellular differentiation, and the immune response. Mutations in the TP53 gene are associated with several cancers such as small cell lung cancer, pancreatic cancer, ovarian serous carcinoma, head and neck squamous cell carcinoma and invasive breast carcinoma.

Quality

ChIP Validation:

View ChIP Validation Data for lot number: 032M4762

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Legal Information

Imprint is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable