The mouse monoclonal antibody STRO-1 recognizes the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.
Immunogen
Human CD34 positive bone marrow cells
Biochem/physiol Actions
STRO-1 plays a vital role as a mesenchymal stem cell (MSC) marker. This 75kDa endothelial protein has a capacity to differentiate into multiple mesenchymal lineages such as hematopoiesis supportive stromal cells with a vascular smooth muscle like phenotype, as well as adipocytes, osteoblasts and chondrocytes. STRO-1 antibody has been used to separate stromal precursors from freshly aspirated bone marrow (BM) cell suspensions.
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Physical form
Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mesenchymal Stem Cell Marker Stro-1 is a 75kd Endothelial Antigen
Hongxiu N, et al.
Biochemical and Biophysical Research Communications, 413(2), 353-357 (2011)
Identification of Stromal Cell Precursors in Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1
Simmons P J, et al.
Blood, 78(1), 55-62 (1991)
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