Cluster of differentiation 4 (CD4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.
The rat monoclonal antibody GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).
Immunogen
Mouse CTL clone V4 cells
Application
The reagent is designed for Flow Cytometry analysis using 1 μg reagent / 1e6 cells in a suspension.
Biochem/physiol Actions
Cluster of differentiation 4 (CD4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for human immunodeficiency virus (HIV)-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Isochromosomes 12p and 9p: parental origin
and possible mechanisms of formation
Dutly F
European Journal of Human Genetics, 6, 140-144 (1998)
Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.
Beckham JC
Journal of clinical immunology, 12, 353-361 (1992)
The role of CD4 on mechanical properties of live cell membrane.
Bui VC and Nguyen TH
Journal of Biomedical Materials Research Part A, 104, 239-244 (2016)
Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2.
Owen GR
Biochemistry, 55, 2227-2237 (2016)
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