SAB4700292
Monoclonal Anti-CD235a antibody produced in mouse
clone HIR2, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-GYPA, Anti-GYPA, (N-terminal), Anti-Glycophorin A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HIR2, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... GYPA(2993)
General description
Glycophorin A (GYPA), also known as CD235a, is an integral membrane sialoglycoprotein, expressed exclusively in erythrocytes. GYPA is characterized with a cytoplasmic tail at the c-terminal end, involved in enhancing trafficking of band 3 to the cell surface, and an N-terminal transmembrane domain involved in increasing the specific activity of band 3 for anion transport. N- glycan of hGYPA consists of ABH blood group antigen.
Immunogen
Synthetic peptide (Human, N-terminal)
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 0.1 μg reagent / 1e6 cells in a suspension
Biochem/physiol Actions
CD235a circulating microparticles might act as a unique systemic biomarker of ongoing formation of thrombi. Increased expression of GYPA is an indication of intra-plaque hemorrhage and it is associated with necrotic cores and macrophage infiltration in coronary atheromas. Human glycophorin A (GPA) facilitates the band 3 anion transport activity at the cell surface within a limited time span during erythroid maturation.
Features and Benefits
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Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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R Suades et al.
Journal of thrombosis and haemostasis : JTH, 13(10), 1776-1786 (2015-08-05)
Local fluid dynamics and exposed atherosclerotic lesions regulate thrombus formation. Activated cells in the attached thrombi release microparticles to the circulation (circulating microparticles [cMPs]); however, their phenotype is unknown. To investigate the specific phenotype of the cMPs released by growing
Mark T Young et al.
The Journal of biological chemistry, 278(35), 32954-32961 (2003-06-19)
Human red cell glycophorin A (GPA) enhances the expression of band 3 anion transport activity at the cell surface of Xenopus oocytes. This effect of GPA could occur in two ways, enhancement of band 3 anion transport function or enhancement
M Hakimi et al.
International journal of molecular medicine, 32(2), 331-338 (2013-06-01)
The aim of this study was to evaluate in detail the histopathological characteristics of endarterectomized carotid atherosclerotic lesions in symptomatic versus asymptomatic patients. Twenty carotid lesions, 10 from asymptomatic and 10 from symptomatic patients who underwent carotid endarterectomy were classified
Sten-Ake Fredriksson et al.
Archives of biochemistry and biophysics, 498(2), 127-135 (2010-05-04)
We previously showed that a small proportion of the O-linked oligosaccharide chains of human glycophorin A (GPA) contains blood group A, B or H antigens, relevant to the ABO phenotype of the donor. The structures of these minor O-glycans have
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