SAB4700024

Monoclonal Anti-CD147-Biotin antibody produced in mouse

clone MEM-M6/1, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-BSG, Anti-BSG-Biotin, Anti-Basigin, Anti-Neurothelin
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: biotin conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: MEM-M6/1, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_001728.2
• UniProt accession no.: P35613
• shipped in: wet ice
• Storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... BSG(682)

Description

General description

The antibody MEM-M6/1 recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes.
Cluster of differentiation 147 (CD147) is a multifunctional trans-membrane glycoprotein and is a member of the immunoglobulin superfamily. It occurs in transmembrane and soluble forms. CD147 is also known as EMMPRIN or basigin (BSG). It is a 57 kDa glycoprotein with two extracellular Ig domains. CD147 is located on human chromosome 19p13.

Immunogen

Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer)

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1:250. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 147 (CD147) is considered as an extracellular matrix metalloproteinase inducer. It participates in several physiological and pathological activities, mainly in tumor invasion and metastasis. CD147 helps in tumor cell-macrophage interactions and stimulates MMPs (matrix metalloproteinases) and vascular endothelial growth factor (VEGF).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable