The ZYX (zyxin) gene is mapped to human chromosome 7q34. It encodes a zinc-binding phosphoprotein, belonging to the focal adhesion complex. It is also localized to actin cytoskeleton.
Immunogen
The antiserum was produced against synthesized peptide derived from human Zyxin around the phosphorylation site of Ser142.
Immunogen Range: 108-157
Biochem/physiol Actions
ZYX (zyxin) controls actin filament assembly, and cell motility. It also participates in the regulation of cell division (mitosis), and cell differentiation processes. ZYX is associated with tumor cell proliferation and migration. It is also known to induce the pathogenesis of colon cancer, and hepatocellular carcinoma. Mechanoresponses with respect to integrin and cadherin-based cell adhesion, shows the involvement of zyxin.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the alpha-catenin-vinculin module
Oldenburg J, et al.
Scientific Reports, 5(29), 17225-17225 (2015)
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Zhou J, et al.
Proceedings of the National Academy of Sciences of the USA, 115(29), E6760-E6769 (2018)
Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma
Sy SMH, et al.
Modern Pathology, 19(8), 1108-1108 (2006)
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