SAB4504535

Anti-phospho-SP1 (pThr⁷³⁹) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 80 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; western blot: 1:500-1:1000
• NCBI accession no.: P08047
• UniProt accession no.: P08047
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... SP1(6667)

Description

General description

Specific protein 1 (Sp1) is a transcription regulator that has a transactivation domain at the N-terminus and a DNA-binding domain at the C-terminus, that contains three zinc fingers (ZF).[1] It belongs to the transcription factor family (3) and is located on human chromosome 12q13.[2]

Immunogen

The antiserum was produced against synthesized peptide derived from human SP1 around the phosphorylation site of Thr739.

Immunogen Range: 706-755

Application

Anti-phospho-SP1 (pThr739) antibody has been used in western blotting and immunohistochemical staining.[3]

Biochem/physiol Actions

Specific protein 1 (Sp1) controls the up- and down-regulation of hCtr1 (human high-affinity copper transporter 1).[1] This gene controls the expression of several genes that participates in differentiation, cell cycle and oncogenesis. SP1 has the ability to bind GC/GT‐rich promoter elements with the help of C(2)H(2)‐type zinc fingers at the C‐terminal domains.[4]

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable