The PER2 (period circadian regulator 2) gene is mapped to human chromosome 2q37.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662.
Immunogen Range: 636-685
Biochem/physiol Actions
PER2 (period circadian regulator 2) possess a physiological and pathological control over the mammalian circadian clock. Abnormal expression of PER2 gene leads to the development of a variety of cancer. Loss of PER2 gene function is observed in the onset of oral squamous cell carcinoma. PER2 might act as an essential biomarker for the same. The reciprocal negative regulation loop of PER2 modulates hepatic circadian clock and the process of aging. PER2 is associated with the pathogenesis of rheumatoid arthritis.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility
Lee H, et al.
Molecular Medicine Reports, 16(1), 422-428 (2017)
Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer
Xiong H, et al.
International Journal of Oncology, 52(1), 279-287 (2018)
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
Wang RH, et al.
Scientific Reports, 6(1), 28633-28633 (2016)
The multiple facets of Per2
Cold Spring Harbor Symposia on Quantitative Biology, 72, 95-104 (2007)
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