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Key Documents

SAB4504174

Sigma-Aldrich

Anti-phospho-Epo-R (pTyr368) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P19235

UniProt accession no.

P19235

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... EPOR(2057)

General description

Erythropoietin (Epo) is a hypoxia-inducible cytokine. EPOR gene has eight exons. It is located on human chromosome 19p13. This gene belongs to the superfamily of cytokine receptors.

Immunogen

The antiserum was produced against synthesized peptide derived from human Epo-R around the phosphorylation site of Tyr368.

Immunogen Range: 341-390

Biochem/physiol Actions

EPOR (erythropoietin receptor) participates in angiogenesis and controls erythropoiesis. EPOR destroys the xenografts of HeLa cells by repressing the ectopic hemoglobin synthesis. Point mutation in EPOR leads to short deletion in congenital erythrocytosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
110917

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A new point mutation in EPOR inducing a short deletion in congenital erythrocytosis.
Chauveau A
British Journal of Haematology, 172(3), 475-477 (2016)
Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19.
Budarf M
Genomics, 8(3), 575-578 (1990)
Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras.
Gross M
British Journal of Haematology, 165(4), 519-528 (2014)
Erythropoietin Receptor Antagonist Suppressed Ectopic Hemoglobin Synthesis in Xenografts of HeLa Cells to Promote Their Destruction
Yasuda Y, et al.
PLoS ONE (2015)

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