EPHB1(ephrin type-B receptor 1) and EPHA2 (EPH receptor A2) belongs to the Eph gene family of receptor tyrosine kinases. EPHB1 is present in venous endothelial cells during embryonic development to adulthood. It is located on human chromosome 3q22.2. EPH receptor A2 codes for a 976 amino acid, type-1 transmembrane protein with extracellular NH2-terminal and cytoplasmic COOH-terminal halves.
Immunogen
The antiserum was produced against synthesized peptide derived from human EPHB1/2 around the phosphorylation site of Tyr594/604.
Immunogen Range: 561-610
Biochem/physiol Actions
EPHB1(ephrin type-B receptor 1) participates in carcinogenesis of RCC (renal cell carcinoma). EPHB1 plays a major role in the growth of nervous and vascular systems. It acts as a biomarker for squamous cell/adenosquamous carcinomas and adenocarcinomas of the gallbladder. EPHA2 (EPH receptor A2) gene is associated with cataracts.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
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