Zeta-chain-associated protein kinase 70 (ZAP70) is a tyrosine kinase, present in T cells and natural killer (NK) cells. It belongs to the spleen tyrosine kinase (Syk) family. This gene is mapped to human chromosome 2q11.
Immunogen
The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr292.
Immunogen Range: 258-307
Biochem/physiol Actions
Zeta-chain-associated protein kinase 70 (ZAP70) plays an important role in T cell receptor (TCR) signaling. It acts as an adaptor protein to increase BCR (B-cell receptor) signaling. This protein is required for T-cell transendothelial migration mediated by C-X-C motif chemokine ligand 12.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
Shah NH, et al.
eLife, 5, e20105-e20105 (2016)
The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system
Alsadeq A, et al.
Haematologica, 102(2), 346-355 (2017)
Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype
Paloneva J, et al.
American Journal of Human Genetics, 71(3), 656-662 (2002)
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Li K, et al.
Annals of Biomedical Engineering, 44(12), 3510-3521 (2016)
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