Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.
Immunogen
The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.
Immunogen Range: 1326-1375
Biochem/physiol Actions
Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
Xu X, et al.
Reproductive Biology and Endocrinology, 9(1), 76-76 (2011)
Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
Pechlivanis S, et al.
Endocrine-Related Cancer, 14(3), 733-740 (2007)
Sequencing analysis of insulin receptor defects and detection of two novel mutations in INSR gene.
Ardon O, et al.
Molecular genetics and metabolism reports, 1, 71-84 (2014)
A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS.
Jin L, et al.
Molecular Human Reproduction, 12(3), 151-155 (2006)
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