Filamin A (FLNA) is an X-linked, ubiquitous actin-binding protein. It is a 280kDa protein consisting of two N-terminal calponin homology domains and a long C-terminal rod-like domain. FLNA is mapped to human chromosome Xq28.
Immunogen
The antiserum was produced against synthesized peptide derived from human Filamin A around the phosphorylation site of Ser2152.
Immunogen Range: 2121-2170
Biochem/physiol Actions
Filamin A (FLNA) has the ability to stop or induce the growth and development of cancer. It regulates the gene transcription of RNA polymerase III in transformed cell lines. In males, mutation in filamin A (FLNA) results in Ehlers-Danlos syndrome.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options
Guerrini R, et al.
Trends in Neurosciences, 31(3), 154-162 (2008)
Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines
Wang J, et al.
The Journal of Biological Chemistry, 291(48), 25239-25246 (2016)
Ehlers-Danlos syndrome with lethal cardiac valvular dystrophy in males carrying a novel splice mutation in FLNA
Ritelli M, et al.
American Journal of Medical Genetics. Part A, 173(1), 169-176 (2017)
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