SAB4503399

Anti-LAT3 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, SLC43A1, Solute carrier family 43 member 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 61 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI accession no.: O75387
• UniProt accession no.: O75387
• shipped in: wet ice
• Storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC43A1(8501)

Description

General description

Anti-LAT3 Antibody detects endogenous levels of total LAT3 protein.

LAT3/SLC43A1 (solute carrier family 43 member 1), a Na⁺-independent neutral L-amino acid transporter, is mapped to human chromosome 11q12.1. It is expressed in liver, skeletal muscle and pancreas.

Immunogen

The antiserum was produced against synthesized peptide derived from human LAT3.

Immunogen Range: 231-280

Biochem/physiol Actions

LAT3/SLC43A1 (solute carrier family 43 member 1) is essential for the growth and activities of podocytes. In prostate cancer cell lines, silencing the expression of LAT3 stops the initiation of mTORC1 (mammalian target of rapamycin complex 1) pathway activation, cell growth and cell cycle both in vitro and in vivo.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable