Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein. The gene encoding it is localized on human chromosome 8q24. PSCA is a 123 amino acid protein, belonging to the thymocyte antigen 1 family.
Immunogen
The antiserum was produced against synthesized peptide derived from human Prostate Stem Cell Antigen.
Immunogen Range: 41-90
Biochem/physiol Actions
Prostate stem cell antigen (PSCA) regulates the cell cycle, has a role in signal transduction pathways and mediates c-Myc-stimulated proliferation. It may have a role in prostate cancer. PSCA has been shown to be expressed in various cancers.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.
Wang M, et al.
Oncotarget, 7(19), 27665-27665 (2016)
Amplification and overexpression of PSCA at 8q24 in invasive micropapillary carcinoma of breast.
Meng F, et al.
Breast Cancer Research and Treatment, 166(2), 383-392 (2017)
PSCA regulates IL-6 expression through p38/NF-KB signaling in prostate cancer.
Liu L, et al.
Prostate, 77(14), 1389-1400 (2017)
PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc.
Li E, et al.
Prostate, 77(16), 1563-1572 (2017)
The influence of PSCA gene variation on its expression and gastric adenocarcinoma susceptibility in the northwest Chinese population.
Zhang W, et al.
International Journal of Molecular Sciences, 16(5), 11648-11658 (2015)
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