SAB4503074

Anti-VGF, C-Terminal antibody produced in rabbit

affinity isolated antibody

• Synonym(s): VGF nerve growth factor inducible, neuro-endocrine specific VGF, neurosecretory protein VGF
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 67 kDa
• species reactivity: rat, human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: O15240
• UniProt accession no.: O15240
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... VGF(7425)

Description

General description

Anti-VGF Antibody detects endogenous levels of total VGF protein.

The VGF (VGF nerve growth factor inducible) gene is mapped to human chromosome 7q22.1 and codes for a neuropeptide, highly expressed in brain.

Immunogen

The antiserum was produced against synthesized peptide derived from human VGF.

Immunogen Range: 454-503

Biochem/physiol Actions

VGF (VGF nerve growth factor inducible) when induced by neurotrophins such as brain-derived neurotrophic factor, is believed to enhance neuron formation in hippocampus. The gene has an influence on a number of biological processes through its proteolytically digested peptide. Processes include metabolic homeostasis, memory, pain, circadian rhythm, regulation of arginine vasopressin secretion, neurodegeneration and neuropsychiatric disorders. Downregulation of the gene was observed in depression and human bipolar disorder. The encoded growth factor has neuroprotective action on impaired neurons in order to support cell survival.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable