Anti-E2A Antibody detects endogenous levels of total E2A protein.
The E2A gene is mapped to human chromosome 19p13.3. The protein encoded is a T-cell factor/lymphoid enhancer factor transcription factor and belongs to helix-loop-helix family.
Immunogen
The antiserum was produced against synthesized peptide derived from human E2A.
Immunogen Range: 321-370
Biochem/physiol Actions
The E2A protein is believed to undergo homo and heterodimerization, that is important for DNA binding. E2A promotes gene transcription by binding to a number of E box sequences. The E2A gene mediates the regulation of B lymphopoiesis. E2A is known to possess oncogenic function. Upregulation of the gene is observed in glioma tissues. It takes part in brain-tumor progression by preventing apoptosis and promote metastasis.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The E2A gene product contains two separable and functionally distinct transcription activation domains.
Aronheim A
Proceedings of the National Academy of Sciences of the USA, 90(17), 8063-8067 (1993)
Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines.
Li R
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 94(3), 247-255 (2016)
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
Cozen W
Nature Communications, 5:3856, 1-23 (2014)
Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function.
Xiang Q
BioMed Research International, 2016, 1-11 (2016)
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