SAB4502780

Anti-ST6GAL1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): α 2,6-ST, β-galactoside α-2,6-sialyltransferase, B-cell antigen CD75, CMP-N-acetylneuraminate-β-galactosamide-α-2,6-sialyltransferase, SIA1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 46 kDa
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P15907
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SIAT1(6480)

Description

General description

β -galactoside α -2, 6-sialyltransferase 1 (ST6GAL1), is a type II membrane protein expressed mainly in the Golgi apparatus. It is encoded by the gene mapped to human chromosome 3q21-28.

Immunogen

The antiserum was produced against synthesized peptide derived from human ST6GAL1.

Immunogen Range: 171-220

Biochem/physiol Actions

β -galactoside α -2, 6-sialyltransferase 1 (ST6GAL1) plays a vital role in transferring sialic acid from cytidine-monophosphate (CMP)-sialic acid onto galactose-containing substrates. ST6GAL1 has an essential role in the regulation of pluripotency and differentiation in human pluripotent stem cells (hPSCs). The encoded protein functions as important regulator of cell survival in several cell death pathways. Overexpression of this enzyme is observed in various cancers, including colon, breast, and epithelial tumor types. Increased expression of ST6GAL1 might affect cell motility and invasion. ST6GAL1 promoter hypermethylation results in loss of ST6GAL1 expression, therefore ST6GAL1 is considered to have a tumor suppressive role of in human bladder carcinogenesis.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable