SAB4502210

Anti-PLD1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, Phospholipase D1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 124 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:1000; immunohistochemistry: 1:50-1:100
• NCBI accession no.: Q13393
• UniProt accession no.: Q13393
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PLD1(5337)

Description

General description

Anti-PLD1 Antibody detects endogenous levels of total PLD1 protein.

The PLD1 (phospholipase D1) gene is mapped to human chromosome 3q26.31. The protein encoded consists of pleckstrin homology and phox homology domains.

Immunogen

The antiserum was produced against synthesized peptide derived from human PLD1.

Immunogen Range: 527-576

Biochem/physiol Actions

PLD1 (phospholipase D1) is responsible for the hydrolysis of phosphatidylcholine to yield phosphatidic acid and choline. It controls EGFR (epidermal growth factor receptor) endocytosis, which is associated with the process of cell proliferation, differentiation, migration and survival. PLD1 regulates the metabolic flexibility of cancer cells to help it maintain its viability and proliferation in response to stress. Upregulation of the gene is observed in gastric cancer. PLD1 might play an important role in allergic disorders such as asthma.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable