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Key Documents

SAB4502088

Sigma-Aldrich

Anti-TAS2R10 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

T2R10, TRB2, Taste receptor family B member 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 35 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9NYW0

UniProt accession no.

Q9NYW0

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TAS2R10(50839)

General description

Anti-TAS2R10 antibody detects endogenous levels of total TAS2R10 protein.
The TAS2R10 (taste 2 receptor member 10) gene belongs to G-protein coupled receptors family. The receptor is particularly expressed in the tongue and palate epithelium.

Immunogen

The antiserum was produced against synthesized peptide derived from human TAS2R10.

Immunogen Range: 122-171

Biochem/physiol Actions

The gene TAS2R10 (taste 2 receptor member 10) encodes a human bitter taste receptor that is induced by bitter compounds. TAS2R10 is known to be stimulated by toxic strychnine and many other compounds, such as sesquiterpene lactones, the alkaloid strychnine, and the synthetic denatonium benzoate. Overexpression of TAS2R10 might prevent the stemness, invasion and migration of cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
61750

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The receptors and coding logic for bitter taste.
Mueller KL
Nature, 434(7030), 225-229 (2005)
Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1?.
Nicholas DA
PLoS ONE, 12(5), 1-24 (2017)
Stephan Born et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 201-213 (2013-01-04)
Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The human TAS2R10 responds to the toxic strychnine and numerous other compounds. The mechanism underlying

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