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Key Documents

SAB4501980

Sigma-Aldrich

Anti-Nuclear Factor 1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CCAAT-box binding transcription factor, CTF, KIAA1439, NF-I/A, NF1-A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

Q12857

UniProt accession no.

P21359

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NF1(4774)

General description

Nuclear factor I A (NF1) belongs to the nuclear factor I family of transcription factors. It exists as four isoforms. The gene encoding NF1 is localized on human chromosome 1p31-p32.

Immunogen

The antiserum was produced against synthesized peptide derived from human Nuclear Factor 1.

Immunogen Range: 11-60

Biochem/physiol Actions

Based on the cell type and promoters, nuclear factor I A (NF1) acts either as an activator or repressor. It has an important role in brain development. NF1 acts as a mediator in glial lineage specification and modulates astrocyte terminal differentiation. The protein has been shown to inhibit apoptosis in glioblastoma cells. Mutations in the NF1 gene have been linked to chromosome 1p32-p31 deletion syndrome.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3110925

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Truncating mutation in NFIA causes brain malformation and urinary tract defects.
Negishi Y, et al.
Human Genome Variation, 2, 15007-15007 (2015)
Loss-of-function variants in NFIA provide further support that NFIA is a critical gene in 1p32-p31 deletion syndrome: A four patient series.
Revah-Politi A, et al.
American Journal of Medical Genetics, 173(12), 3158-3164 (2017)
A novel NFIA-NF?B feed-forward loop contributes to glioblastoma cell survival.
Lee J, et al.
Neuro-Oncology, 19(4), 524-534 (2017)
Linda Marie Starnes et al.
Blood, 114(9), 1753-1763 (2009-06-23)
It is generally conceded that selective combinations of transcription factors determine hematopoietic lineage commitment and differentiation. Here we show that in normal human hematopoiesis the transcription factor nuclear factor I-A (NFI-A) exhibits a marked lineage-specific expression pattern: it is upmodulated

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