Myogenic factor 5 (MYF5) regulates the determination of skeletal myoblasts during embryonic development. Inactivation of MYF5 in mice results in abnormal development of the ribs, which eventually leads to perinatal death. The gene encoding this protein is localized on human chromosome 12q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human MYF5.
Immunogen Range: 21-70
Application
Anti-MYF5 antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Sonic hedgehog is required for neural crest-dependent patterning of the intrinsic tongue musculature
Shigeru O, et al.
bioRxiv, 154443-154443 (2017)
Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106
Cupelli L, et al.
Cell, 72(2-3), 250-251 (1996)
Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle
Anita H, et al.
European Journal of Cell Biology, 96(1), 47-60 (2017)
Mice carrying null mutations in the myogenic regulatory factors Myf-5 or MyoD have apparently normal skeletal muscle. To address whether these two factors functionally substitute for one another in myogenesis, mice carrying mutant Myf-5 and MyoD genes were interbred. While
The Myf-5 gene, a member of the myogenic basic HLH factor family, has been inactivated in mice after homologous recombination in ES cells. Mice lacking Myf-5 were unable to breathe and died immediately after birth, owing to the absence of
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