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Key Documents

SAB4501789

Sigma-Aldrich

Anti-LTK antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Leukocyte tyrosine kinase receptor precursor, Protein tyrosine kinase-1, TYK1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 91 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
western blot: 1:500-1:1000

NCBI accession no.

P29376

UniProt accession no.

P29376

shipped in

wet ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LTK(4058)

General description

Anti-LTK Antibody detects endogenous levels of total LTK protein.
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase. It is a member of the insulin receptor family. LTK is expressed in pre-B cells and brain. It is mapped to human chromosome 15q15. LTK has an ATG translational initiation codon, a secretory signal sequence, a 347 amino acid extracellular domain along with transmembrane and intracellular kinase domains.

Immunogen

The antiserum was produced against synthesized peptide derived from human LTK.

Immunogen Range: 206-255

Application

Overexpression of leukocyte tyrosine kinase (LTK) results in leukemia. It participates in cell growth and anti-apoptotic signaling. This protein acts as a cell surface receptor for an unidentified cellular growth factor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3110512

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The ltk gene encodes a novel receptor?type protein tyrosine kinase.
Krolewski JJ and Dalla?Favera R
The Embo Journal, 10(10), 2911-2919 (1991)
Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer.
Christina F, et al.
Cancer Letters, 196(1), 65-67 (2003)
Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.
Ueno H, et al.
Journal of Biochemistry, 271(44), 27707-27714 (1996)
ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation.
Roll JD and Reuther GW
PLoS ONE, 7(2), 31733-31733 (2012)

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