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Key Documents

SAB4501424

Sigma-Aldrich

Anti-HNRNP K antibody produced in rabbit

affinity isolated antibody

Synonym(s):

65 kDa phosphoprotein, CSBP, DC-stretch binding protein, Heterogeneous nuclear ribonucleoprotein K, hnRNP-K

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

P61978

UniProt accession no.

P61978

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HNRNPK(3190)

General description

Anti-HNRNP K Antibody detects endogenous levels of total HNRNP K protein.
Heterogeneous nuclear ribonucleoprotein K (HNRNP K) is encoded by the gene mapped to human chromosome 9q21.32. HNRNP K encodes a nucleic acid binding protein that shuttles between nucleus and the cytoplasm. The encoded protein contains three K homology (KH) domains that is involved in RNA and/or single strand DNA binding.

Immunogen

The antiserum was produced against synthesized peptide derived from human hnRNP K.

Immunogen Range: 250-299

Biochem/physiol Actions

Heterogeneous nuclear ribonucleoprotein K (HNRNP K) plays a vital role in regulation of various cellular processes such as chromatin remodelling, transcription, RNA stability and splicing, translation and signal transduction. In addition, it also mediates transcriptional responses to DNA damage. It is an essential element in p53/HDM2 (human double minute 2) pathway. Mutations in the gene leads to melanoma. Haploinsufficiency of the gene is associated with the development of congenital malformation syndrome, characterized with intellectual disability.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
211042

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hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage
Moumen A, et al.
Cell, 123, 1065-1078 (2005)
GeneMatcher aids in the identification of a new malformation syndrome with intellectual disability, unique facial dysmorphisms, and skeletal and connective tissue abnormalities caused by de novo variants in HNRNPK.
Au PYB, et al.
Human Mutation, 36, 1009-1014 (2015)
Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma.
Wen F, et al.
Annals of Surgical Oncology, 17, 2619-2627 (2010)

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