SAB4501285

Anti-TRIM59 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): RING finger protein 104, Tumor suppressor TSBF-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 47 kDa
• species reactivity: human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q8IWR1
• UniProt accession no.: Q8IWR1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TRIM59(286827)

Description

General description

Anti-TRIM59 Antibody detects endogenous levels of total TRIM59 protein.

TRIM59 (tripartite-59) belongs to the tripartite motif (TRIM) family of proteins. It has a RING domain, one or two B-box motifs and a coiled-coil region. It is located on human chromosome 3q25.

Immunogen

The antiserum was produced against synthesized peptide derived from human TRIM59.

Immunogen Range: 191-240

Biochem/physiol Actions

Suppression of tripartite-59 (TRIM59) blocks the multiplication and migration of cervical cancer cells. In prostate cancer models, TRIM59 serves as a proto-oncogene that affects Ras and RB signal pathways. It also induces the multiplication and migration of non-small cell lung cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable