Anti-SESN1 Antibody detects endogenous levels of total SESN1 protein.
Sestrins are stress-inducible proteins. The SESN1 (sestrin 1) gene is located on human chromosome 6q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human SESN1.
Immunogen Range: 271-320
Biochem/physiol Actions
Knockdown of SESN1 (sestrin 1) blocks cell cycle progression. Sestrin 1 acts as an antioxidant and as inhibitor of target of rapamycin complex 1. It is considered as a p53 target gene and it helps to connect between genotoxic stress, p53 and the mTOR signaling pathway.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
Budanov AV and Karin M
Cell, 134(3), 451-460 (2008)
A study of recombinant human sestrin 1 and sestrin 2 proteins produced in a prokaryotic system
Rai N, et al.
Molekuliarnaia Biologiia, 51(3), 416-425 (2017)
Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest
Zhang Y, et al.
DNA Repair, 7, 1835-1845 (2008)
Sestrins at the crossroad between stress and aging
Lee JH, et al.
Aging (Albany. NY.), 2 (2010)
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