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Key Documents

SAB4500954

Sigma-Aldrich

Anti-SEPT8 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

KIAA0202, Septin-8

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100 μG
$392.00

$392.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
$392.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$392.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

Q92599

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SEPT8(23176)

General description

Anti-SEPT8 Antibody detects endogenous levels of total SEPT8 protein.

Septins are cytoskeletal GTPases. SEPT8 (septin 8) belongs to septin family. It is expressed in brain. It is also present in heart, aorta, prostate, testis and ovary. It is located on human chromosome 5q31.

Immunogen

The antiserum was produced against synthesized peptide derived from human SEPT8.

Immunogen Range: 170-219

Biochem/physiol Actions

In platelets, SEPT8 (septin 8) participates in granula secretion. It also participates in cytokinesis, vesicle trafficking and exocytosis. The protein mitogen-activated protein kinase-activated protein kinase 5 (MK5) phosphorylates and modulates septin 8, which interacts with various synaptic vesicle proteins and may participate in the release of neurotransmitters.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3118514

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Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5
Blaser S, et al.
The Journal of Pathology, 210, 103-110 (2006)
Septin 8 is an interaction partner and in vitro substrate of MK5
Shiryaev A, et al.
World Journal of Biological Chemistry, 3, 98-109 (2012)
Septin expression in proliferative retinal membranes
Xin X, et al.
The Journal of Histochemistry and Cytochemistry, 55(11), 1089-1094 (2007)
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Naka I, et al.
Malaria Journal (2009)

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