Aprataxin and PNKP-like factor (APLF) is also called as PALF and Xip1. It is located in the nucleus. APLF has a forkhead-associated (FHA) domain and two unique poly (ADP-ribose)-binding zinc finger (PBZ) domains in its C-terminal region. This gene is mapped to human chromosome 2p13.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human APLF.
Immunogen Range: 82-131
Biochem/physiol Actions
Aprataxin and PNKP-like factor (APLF) acts as a DNA repair factor. The forkhead-associated (FHA) domain of APLF helps to bind to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. Other domains of APLF recruites APLF to sites of DNA damage.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF).
Shirodkar P, et al.
The Journal of Biological Chemistry, 288(27), 19604-19613 (2013)
Rapid whole genome sequencing identifies a novel GABRA1 variant associated with West syndrome.
Farnaes L, et al.
Cold Spring Harbor molecular case studies, 3(5), mcs-a001776 (2017)
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