SAB4500626

Anti-DCT antibody produced in rabbit

affinity isolated antibody

• Synonym(s): DCT, DT, L-dopachrome δ-isomerase, L-dopachrome tautomerase, Tyrosinase-related protein 2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 59 kDa
• species reactivity: human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI accession no.: P40126
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TYRP2(1638)

Description

General description

Anti-DCT Antibody detects endogenous levels of total DCT protein.

Dopachrome tautomerase (DCT) is also termed as tyrosinase-related protein 2 (TYRP2). It is present in melanocytes, RPE (retinal pigment epithelium) cells and HaCaTs (basal keratinocytes). It is located on human chromosome 13q32.

Immunogen

The antiserum was produced against synthesized peptide derived from human DCT.

Immunogen Range: 51-100

Biochem/physiol Actions

Dopachrome tautomerase (DCT) participates in the production of melanin in melanosomes and also in the detoxification of the melanin precursors. It restricts the destructions induced by chemotherapeutic agents like X-ray or UVB (ultraviolet B) and gamma irradiation in melanoma cells and reduces the susceptibility of cell to oxidative stress.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable