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Key Documents

SAB4500507

Sigma-Aldrich

Anti-CSK antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C-SRC kinase, Protein-tyrosine kinase CYL

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P41240

UniProt accession no.

P41240

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSK(1445)

General description

The C-terminal Src kinase (CSK) gene is mapped to human chromosome 15q24.1. Anti-CSK Antibody detects endogenous levels of total CSK protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human CSK.

Immunogen Range: 31-80

Biochem/physiol Actions

C-terminal Src kinase (CSK) is known to support dengue virus replication. CSK negatively controls Src, an oncogenic protein found to be upregulated in various types of cancer. CSK is responsible for Src phosphorylation at tyrosine 530, which inhibits its activity. It controls immune response, by preventing T cell activation through its association with lymphoid-specific phosphatase. CSK possesses SH2 domain, a regulatory domain that mediates its binding to scaffold proteins for membrane translocation. This regulation is known to elevate CSK′s activity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3110598

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Genome-wide association analyses on blood pressure using three different phenotype definitions
JW Park, et al.
Genomics & informatics, 8(3), 108-115 (2010)
Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schonlein purpura (IgA vasculitis)
Lopez MR, et al.
Scientific reports, 17(1), 286-286 (2015)
Regulation of the SRC family kinases by Csk
Okada Masato
International Journal of Biological Sciences, 8(10), 1385-1385 (2012)
Rinki Kumar et al.
Scientific reports, 6, 30490-30490 (2016-07-28)
We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication. Knock-down of Csk expression by siRNAs or inhibition of Csk by an
Bo Kyung Jeon et al.
Scientific reports, 5, 12725-12725 (2015-08-04)
Mitogen-activated protein kinases (MAPKs) are key signal transducers involved in various cellular events such as growth, proliferation, and differentiation. Previous studies have reported that H2O2 leads to phosphorylation of extracellular signal-regulated kinase (ERK), one of the MAPKs in endothelial cells.

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