SAB4500387
Anti-Collagen VI α1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CO6A1, Collagen α-1(VI) chain
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 108 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COL6A1(1291)
General description
Anti-Collagen VI α1 Antibody detects endogenous levels of total Collagen VI α1 protein.
Collagen type VI α1 chain (COL6A1) is encoded by the gene mapped to long arm of human chromosome 21q22.3. Collagen VI is widely expressed in connective tissue.
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen VI alpha1.
Immunogen Range: 191-240
Immunogen Range: 191-240
Application
Anti-Collagen VI α1 antibody produced in rabbit has been used in immunohistochemistry and cytofluorimetric analysis.[1]
Biochem/physiol Actions
Collagen type VI α1 chain (COL6A1) plays a vital role in tumor metastasis. Mutations in the gene leads to Bethlem myopathy. Increased expression of the gene can be considered as an important marker for poor prognosis of clear cell renal cell carcinoma patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Novel mutations in collagen VI genes Expansion of the Bethlem myopathy phenotype.
Scacheri PC, et al.
Neurology, 58(4), 593-602 (2002)
Viktorija Aleksiuk et al.
Biomedicines, 11(9) (2023-09-28)
Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no effective treatments are currently available. Arterial hypertension is a common comorbidity in OA patients, and antihypertensive drugs, such as nifedipine (NIF), may affect the
Down syndrome--a gene dosage disease caused by trisomy of genes within a small segment of the long arm of chromosome 21, exemplified by the study of effects from the superoxide-dismutase type 1 (SOD-1) gene.
Anneren G, et al.
APMIS. Supplementum, 40, 71-79 (1993)
Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients
Wan F, et al.
Oncotarget, 6(29), 27378-27378 (2015)
William W MacDonald et al.
Investigative ophthalmology & visual science, 63(6), 8-8 (2022-06-08)
Secreted protein, acidic and rich in cysteine (SPARC) elevates intraocular pressure (IOP), increases certain structural extracellular matrix (ECM) proteins in the juxtacanalicular trabecular meshwork (JCT), and decreases matrix metalloproteinase (MMP) protein levels in trabecular meshwork (TM) endothelial cells. We investigated
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