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Key Documents

SAB4500340

Sigma-Aldrich

Anti-HSP20 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

HSPB6, Heat-shock 20 kDa like-protein p20

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 17 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HSPB6(126393)

General description

Anti-HSP20 Antibody detects endogenous levels of total HSP20 protein.
Heat shock protein 20 (HSP20)/HSPB6 (heat shock protein family B member 6)) belongs to the small heat shock protein family. It is located on human chromosome 19q13. It is present in the brain, stomach, liver, lung, kidney, blood, smooth muscle, skeletal muscle and cardiac tissue.

Immunogen

The antiserum was produced against synthesized peptide derived from human HSP20.

Immunogen Range: 5-54

Biochem/physiol Actions

Heat shock protein 20 (HSP20) is involved in asthma, intimal hyperplasia and insulin resistance. It controls myometrial activity. Overexpression of Hsp20 helps to increase cardiac function and provides cardioprotection against β-agonist-mediated apoptosis and ischemia/reperfusion injury ex vivo and in vivo.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hsp20 and Its Cardioprotection
Fan GC, et al.
Trends in Cardiovascular Medicine, 15(4), 138-141 (2005)
Regulation of apoptosis by heat shock proteins
Kennedy D, et al.
IUBMB Life, 66(5), 327-338 (2014)
Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity
Karolczak-Bayatti M, et al.
The Journal of Biological Chemistry, 286(39), 34346-34355 (2011)
Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis
Ju YT, et al.
Journal of Cellular Biochemistry, 116(2), 277-286 (2015)

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