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Key Documents

SAB4500169

Sigma-Aldrich

Anti-CD3EAP antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-sense to ERCC-1 protein, ASE-1, CD3-ε-associated protein, DNA-directed RNA polymerase I subunit RPA34, RNA polymerase I-associated factor PAF49

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 54 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

O15446

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPA34(10849)

General description

The CD3EAP (CD3e molecule, epsilon-associated protein) gene is mapped to human chromosome 19q13.3. It encodes a DNA-dependent RNA polymerase I subunit RPA34 (replication protein A34). This protein is localized to the nucleolus, in the fibrillar centers during interphase and the nucleolus organizer regions of the chromosomes during cell division. Anti-CD3EAP antibody detects endogenous levels of total CD3EAP protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human CD3EAP.

Immunogen Range: 441-490

Biochem/physiol Actions

The CD3EAP (CD3e molecule, epsilon-associated protein) gene participates in the process of programmed cell death and ribosomal RNA transcription. CD3EAP expression is implicated in the pathogenesis of non-small cell lung cancer (NSCLC).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3115463

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19p13. 3-GADD45B common variants and 19q13. 3-PPP1R13L and 19q13. 3-CD3EAP in lung cancer risk among Chinese
Hou W, et al.
Chemico-Biological Interactions, 277, 74-78 (2017)
Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women
Yin J, et al.
Gene, 524(2), 228-231 (2013)
Different splicing isoforms of ERCC1 affect the expression of its overlapping genes CD3EAP and PPP1R13L, and indicate a potential application in non-small cell lung cancer treatment
Zhang G, et al.
International Journal of Oncology, 52(6), 2155-2165 (2018)
Association of chromosome 19 to lung cancer genotypes and phenotypes.
Wang X
Cancer Metastasis Reviews, 34(2), 217-226 (2015)

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