Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein.
Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR).
Immunogen
The antiserum was produced against synthesized peptide derived from human TRXR2.
Immunogen Range: 471-520
Biochem/physiol Actions
Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation
Kim MR, et al.
Biochemical and Biophysical Research Communications, 304(1), 119-124 (2003)
The Genes Associated with RNA Editing and Glioma on the Chromosome 22q.
Wang G and Tian Y
Advances in Medical Sciences, 2(1) (2014)
Mitochondrial thioredoxin system effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis.
Patenaude A, et al.
The Journal of Biological Chemistry, 279(26), 27302-27314 (2004)
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Kariz S, et al.
Diabetes Research and Clinical Practice, 108(2), 323-328 (2015)
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