SAB4500110

Anti-C/EBP-α antibody produced in rabbit

affinity isolated antibody

• Synonym(s): C/EBP α, CCAAT/enhancer binding protein α, CCAAT/enhancer binding protein (C/EBP) α, CEBPA
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 37 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P49715
• UniProt accession no.: P49715
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CEBPA(1050)

Description

General description

Anti-C/EBP-α Antibody detects endogenous levels of total C/EBP-α protein.

CCAAT/enhancer-binding protein α (C/EBPα) is encoded by the gene mapped to human chromosome 19q13.1. The encoded protein belongs to the basic leucine zipper (bZIP) family of transcription factors. CEBPA is highly expressed in differentiated tissues.

Immunogen

The antiserum was produced against synthesized peptide derived from human C/EBP-alpha.

Immunogen Range: 6-55

Biochem/physiol Actions

The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) plays an essential role in tumor progression. It blocks β-catenin to repress lung adenocarcinoma cell invasion and migration. CEBPA is implicated in the regulation of hematopoiesis and terminal differentiation of various cell types like adipocytes, hepatocytes and different epithelial cells. Variations in the gene expression has been observed in 5–10% of cases of acute myeloid leukemia (AML).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable