PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) is also known as polycystin-L/ transient receptor potential polycystin-3 (TRPP3). It is expressed in brain, kidney, heart, skeletal muscle, spleen, testis, retina and in the bipolar neurons in the tongue taste buds. TRPP3 is present on the surface membrane and/or endoplasmic reticulum membrane of cells. It belongs to the PKD2 gene family. PKD2L1 is mapped to human chromosome 10q25.
Immunogen
Synthetic peptide of human PKD2L1
Biochem/physiol Actions
PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) participates in hedgehog signaling, intestinal development and sour tasting. It controls ciliary Ca2+ concentration. Mutations in PKD2 results in autosomal dominant kidney disease (ADPKD).
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Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Certificates of Analysis (COA)
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Regulation of TRPP3 channel function by N-terminal domain palmitoylation and phosphorylation.
Zheng W, et al.
The Journal of Biological Chemistry, 291(49), 25678-25691 (2016)
Identification ofPKD2L, a HumanPKD2-Related Gene: Tissue-Specific Expression and Mapping to Chromosome 10q25.
Wu G, et al.
Genomics, 54(3), 564-568 (1998)
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