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SAB4301658

Sigma-Aldrich

Anti-CSPG4

affinity isolated antibody

Synonym(s):

HMW-MAA, MCSP, MCSPG, MSK16, NG2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: 1:20-1:100
western blot: 1:500-1:2000

accession no.

NP_001888

UniProt accession no.

Q6UVK1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSPG4(1464)

General description

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

Biochem/physiol Actions

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

Features and Benefits

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Physical form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
Wang J, et al.
PLoS ONE, 6(7), e23062-e23062 (2011)
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
Eisenmann KM, et al.
Nature Cell Biology, 1(8), 507-513 (1999)
A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
Staub E, et al.
Febs Letters, 527(1-3), 114-118 (2002)
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Svendsen A, et al.
Acta Neuropathologica, 122(4), 495-510 (2011)
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C, et al.
Molecular Oncology, 1(4), 425-430 (2008)
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