Interleukin 3 receptor subunit α alpha (IL3RA or CD123) gene is localized in the X and Y chromosomes. It comprises a highly mobile N-terminal domain (NTD) region and fibronectin type III (FnIII) domain. CD123 is expressed on early hematopoietic cells and is a type I cytokine receptor.
Immunogen
Synthetic peptide of human interleukin 3 receptor, alpha (low affinity)
Biochem/physiol Actions
Elevated expression of IL3RA is reported in chronic myeloid leukemia (CML).) It may serve as a therapeutic potential to treat acute myelogenous leukemia (AML).
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Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Recent studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). LSCs have been documented for nearly all AML subtypes and have been phenotypically described
Journal of medical genetics, 33(11), 906-911 (1996-11-01)
Colony stimulating factor-2 receptor alpha (CSF2RA) and interleukin-3 receptor alpha (IL3RA), two genes from the chromosome Xp and Yp pseudoautosomal region (PAR), have been suggested as candidate genes for short stature in Turner syndrome. We report three girls with X;Y
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits
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