SAB4301448
Anti-phospho-VE-Cadherin (pTyr731) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
7B4 antigen, CD144 antigen, CDH5, VE-cadherin, Vascular endothelial cadherin
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
130 kDa
species reactivity
rat, mouse, human
concentration
1.0 mg/mL
technique(s)
western blot: 1:500-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_001786.2
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr731)
Gene Information
human ... CDH5(1003)
General description
Vascular endothelial cadherin (VE-cadherin) or CDH5 gene is mapped to human chromosome 16q21. It comprises extracellular cadherin (EC) domains that take up a strand-swapped dimers structure.
Specificity
The antibody detects endogenous level of VE-Cadherin only when phosphorylated at tyrosine 731.
Immunogen
Peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y(p)-G-Y) derived from Human VE-Cadherin.
Application
Anti-phospho-VE-Cadherin (pTyr731) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Vascular endothelial cadherin (VE-cadherin) plays a key role in maintaining membrane integrity and vascular endothelium. It mediates endothelial cell-cell adhesion in particular at the adherens junctions and participates in leukocyte trafficking. VE-cadherin is also needed for embryonic angiogenesis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Julia Brasch et al.
Journal of molecular biology, 408(1), 57-73 (2011-01-29)
Vascular endothelial cadherin (VE-cadherin), a divergent member of the type II classical cadherin family of cell adhesion proteins, mediates homophilic adhesion in the vascular endothelium. Previous investigations with a bacterially produced protein suggested that VE-cadherin forms cell surface trimers that
Mintu Pal et al.
Experimental cell research, 368(2), 137-146 (2018-04-21)
The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell polarity and loss of expression of the cell- cell adhesion molecule like E-cadherin and acquired mesenchymal cells marker called N-Cadherin. This phenotypical changes of E-M plasticity of
Lihua Ying et al.
American journal of physiology. Lung cellular and molecular physiology, 315(1), L66-L77 (2018-03-31)
Compromised pulmonary endothelial cell (PEC) barrier function characterizes acute respiratory distress syndrome (ARDS), a cause of substantial morbidity and mortality. Survival from ARDS is greater in children compared with adults. Whether developmental differences intrinsic to PEC barrier function contribute to
Maria Grazia Lampugnani et al.
Journal of cell science, 123(Pt 7), 1073-1080 (2010-03-25)
Little is known about the molecular mechanisms that regulate the organization of vascular lumen. In this paper we show that lumen formation correlates with endothelial polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal
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