SAB4301419

Anti-phospho-NF-κB p100 (pSer⁸⁷²) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, Nuclear factor NF-kappa-B p100 subunit, Oncogene Lyt-10
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 100 kDa
• species reactivity: rat, human, mouse
• concentration: 1.0 mg/mL
• technique(s): western blot: 1:500-1:1000 (Cell Lysate)
• isotype: IgG
• accession no.: NP_001070962.1
• UniProt accession no.: Q00653
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer872)
• Gene Information: human ... NFKB2(4791)

Description

General description

Nuclear factor kappa B subunit 2 (NFKB2) encodes the nuclear factor kappa B2 (NF-κB), a nuclear transcription factor. NF-κB is evolutionarily highly conserved. In human chromosome, the gene NFKB2 is localized on 10q24.

Specificity

The antibody detects endogenous level of NF-κB p100 only when phosphorylated at serine 872.

Immunogen

Peptide sequence around phosphorylation site of serine872(S-Q-S(p)-V-E) derived from Human NF-κB p100 .

Biochem/physiol Actions

Regulation of nuclear factor kappa B subunit 2 (NFKB2) includes cytoplasmic-nuclear shuttling and its transcriptional activity. NF-κB plays a key role in regulating the immune response and apoptotic processes. It is necessary for combating diseases like arthritis, autoimmune diseases and asthma. Mutations in NFKB2 impairs post translational processing of p100 preventing nuclear translocation of p52. This leads to common variable immunodeficiency and adrenal insufficiency. Mutation also affects canonical and non-canonical pathway of NFKB2 signalling and causes autosomal dominant primary antibody deficiency (PAD). chromosomal aberrations in C-terminal region of NFKB2 is associated lymphoid malignancies.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable