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SAB4301171

Sigma-Aldrich

Anti-MT-CO2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

COII, COXII, MTCO2

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100 μL
$380.00

$380.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μL
$380.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$380.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

26 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1:10- 1:50
western blot: 1:500-1:2000 (Cell Lysate)

isotype

IgG

accession no.

P00403

UniProt accession no.

P00403

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MT-CO2(4513)

General description

Mitochondrially encoded cytochrome c oxidase II (MT-CO2) is a key subunit of cytochrome c oxidase, which is the terminal enzyme involved in the oxidative phosphorylation complexes.

Specificity

The antibody detects endogenous levels of total MT-CO2 protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human mitochondrially encoded cytochrome c oxidase II

Biochem/physiol Actions

Polymorphism in mitochondrially encoded cytochrome c oxidase II (MT-CO2) might alter electron transfer from cytochrome c to the bimetallic center of the catalytic subunit I. Aberrations in MT-CO2 expression has been observed in prostate cancer patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
492636717

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Mitochondrial cytochrome c oxidase subunit II variations predict adverse prognosis in cytogenetically normal acute myeloid leukaemia.
Silkjaer T, et al.
European Journal of Haematology, 91(4), 295-303 (2013)
Altered expression of 12S/MT-RNR1, MT-CO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer.
Abril J, et al.
Prostate, 68(10), 1086-1096 (2008)
A novel MT-CO2 m.8249G?>?A pathogenic variation and the MT-TW m.5521G?>?A mutation in patients with mitochondrial myopathy
Mkaouar-Rebai E, et al.
Mitochondrial DNA, 25(5), 394-399 (2014)

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