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Key Documents

SAB4301116

Sigma-Aldrich

Anti-CRMP5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CRAM, CRMP-5, Collapsin response mediator protein 5, DPYSL5, Ulip6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

62 kDa

species reactivity

human, mouse, rat

concentration

0.5 mg/mL

technique(s)

immunohistochemistry: 1:10- 1:50
western blot: 1:200-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_001240652.1

UniProt accession no.

Q9BPU6

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DPYSL5(56896)

General description

Dihydropyrimidinase like 5 (DPYSL5) or collapsin response mediator protein 5 (CRMP5) is a cytosolic protein. It is expressed in regions of neurogenesis in the brain. CRMP5 is part of the CRMP cytosolic phosphoprotein family and the gene encoding it is localized on human chromosome 2p23.3.

Specificity

The antibody detects endogenous level of total CRMP5 protein.

Immunogen

Synthetic peptide corresponding to a region derived from 504-518 amino acids of Human Collapsin response mediator protein 5

Biochem/physiol Actions

Collapsin response mediator protein 5 (CRMP5) or dihydropyrimidinase like 5 (DPYSL5) has a role in the development and repair of the nervous system. It has been associated with paraneoplastic neurologic syndromes and is a biomarker for high-grade lung neuroendocrine carcinomas.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
352231174

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CRMP5 controls glioblastoma cell proliferation and survival through notch-dependent signaling.
Moutal A, et al.
Cancer Research, 75(17), 3519-3528 (2015)
Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5.
Ponnusamy R and Lohkamp B
Journal of Neurochemistry, 125(6), 855-868 (2013)
Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.
Bien S A, et al.
Diabetologia, 60(12), 2384-2398 (2017)

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