Nuclear export mediator factor (NEMF), also known as Sdccag1 (Serologically Defined Colon Cancer Antigen 1) encodes a protein exhibiting tumor suppression property.It consists of four prominent domains: the N- and C-lobe connected by a coiled-coil to the middle (M) domain.
Specificity
The antibody detects endogenous levels of total NEMF protein.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human nuclear export mediator factor
Application
Anti-NEMF antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:25 - 1:100 and western blot at a dilution of 1:200-1:1000.
Biochem/physiol Actions
Nuclear export mediator factor (NEMF) is involved in the recruitment of Listerin to stalled ribosomes. It forms a complex with the nascent chain-containing 60S-Listerin and recruits and stabilizes Listerin′s N-terminal domain. It plays a vital role in mediating nuclear export. Inactivation of Sdccag1 expression leads to the transformation of human lung cancer cells.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
During ribosome-associated quality control, stalled ribosomes are split into subunits and the 60S-housed nascent polypeptides are poly-ubiquitinated by Listerin. How this low-abundance ubiquitin ligase targets rare stall-generated 60S among numerous empty 60S is unknown. Here, we show that Listerin specificity
We previously showed that the Drosophila DNA binding homeodomain of Prospero included a 28 amino-acid sequence (HDA) that functions as a nuclear export signal. We describe here the identification of a protein we named Caliban, which can directly interact with
Assignment of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization.
D Carbonnelle et al.
Cytogenetics and cell genetics, 86(3-4), 248-249 (1999-11-27)
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