SAB4300478

Anti-PDGFRB (Ab-751) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CD140B antibody produced in rabbit, Anti-JTK12 antibody produced in rabbit, Anti-PDGF-R-beta antibody produced in rabbit, Anti-PDGFR antibody produced in rabbit, Anti-platelet-derived growth factor receptor, beta polypeptide antibody produced in rabbit
• MDL number: MFCD00164777
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~190 kDa
• species reactivity: rat, human
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (V-D-Y-V-P)
• NCBI accession no.: NP_002600.1
• UniProt accession no.: P09619
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PDGFRB(5159)

Description

General description

Platelet derived growth factor receptor β (PDGFRB) is encoded by the gene mapped to human chromosome 5q32. The encoded protein is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer.

Immunogen

Peptide sequence around aa. 749-753 (V-D-Y-V-P), according to the protein PDGFRB.

Biochem/physiol Actions

PDGFRB (platelet derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome, which is an autosomal-dominant disorder. Release of PGDFB by endothelial cells results in the activation of this receptor, which is essential for the recruitment of PDGFRB+ vascular smooth muscle cells and pericytes during blood vessel formation. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

PDGF Receptor ? encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable