SAB4300366

Anti-TP53 (Ab-33) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-FLJ92943 antibody produced in rabbit, Anti-LFS1 antibody produced in rabbit, Anti-TRP53 antibody produced in rabbit, Anti-p53 antibody produced in rabbit, Anti-tumor protein p53 antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~53 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (V-L-S-P-L)
• NCBI accession no.: NP_000537.3
• UniProt accession no.: P04637
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TP53(7157)

Description

Immunogen

Peptide sequence around aa. 31-35 (V-L-S-P-L), according to the protein TP53.

Features and Benefits

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Target description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable