Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

SAB4300280

Sigma-Aldrich

Anti-phospho-CDK6 (pTyr24) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC59692 antibody produced in rabbit, Anti-PLSTIRE antibody produced in rabbit, Anti-STQTL11 antibody produced in rabbit, Anti-cyclin-dependent kinase 6 antibody produced in rabbit

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~36 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-A-YP-G-K)

NCBI accession no.

NP_001138778.1

UniProt accession no.

Q00534

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr24)

Gene Information

human ... CDK6(1021)

General description

CDK6 (cyclin dependent kinase 6) is a serine/threonine kinase. It is a human PLSTIRE gene product that is located on chromosome 7q21.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 24 (G-A-Y(p)-G-K), according to the protein CDK6.

Biochem/physiol Actions

CDK6 (cyclin dependent kinase 6) participates in the regulation of cell‐cycle, hence it acts as a target for cancer therapy. Upregulation of CDK6 has been observed in various malignancies like leukemia and lymphomas. In hematopoietic stem cells, CDK6 modulates the exit of quiescence.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
951411543

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein
Hernandez Maganhi S, et al.
Protein Science (2017)
In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene
Hayette S, et al.
Blood (2003)
MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL
van der Linden MH, et al.
Cell Cycle (2014)
CDK6 levels regulate quiescence exit in human hematopoietic stem cells
Laurenti E, et al.
Cell Stem Cell (2015)
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
Meyerson M and Harlow E
Molecular and Cellular Biology (1994)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service