SAB4300147

Anti-phospho-YWHAZ (pSer⁵⁸) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-KCIP-1 antibody produced in rabbit, Anti-MGC111427 antibody produced in rabbit, Anti-MGC126532 antibody produced in rabbit, Anti-MGC138156 antibody produced in rabbit, Anti-tyrosine 3-monooxygenase / tryptophan 5-monooxygenase activation protein, zeta polypeptide antibody produced in rabbit
• MDL number: MFCD01324139
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~28 kDa
• species reactivity: rat, mouse, human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (R-S-SP-W-R)
• NCBI accession no.: NP_001129171.1
• UniProt accession no.: P63104
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer58)
• Gene Information: human ... YWHAZ(7534)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 58 (R-S-S(p)-W-R), according to the protein YWHAZ.

Features and Benefits

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Target description

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable