SAB4200687
Monoclonal Anti-NCOR2/SMRT antibody produced in mouse
clone SMRT 5.1, purified from hybridoma cell culture
Synonym(s):
CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
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$542.02
$542.02
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100 μL
$542.02
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
$542.02
List Price$657.00Save 18%Web-Only Promotion
Available to ship onApril 29, 2025Details
Request a Bulk Order
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SMRT 5.1, monoclonal
form
buffered aqueous solution
mol wt
antigen ~270 kDa
species reactivity
human, mouse, canine, bovine, rat
concentration
~1 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using nuclear extract of human HeLa cells.
immunofluorescence: 5-10 μg/mL using human HeLa cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CHD5(26038)
General description
Monoclonal Anti-NCOR2/SMRT (mouse IgG1 isotype) is derived from the hybridoma SMRT5.1 produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the C-terminal region of GST-tagged SMRT protein. Silencing mediator for retinoid or thyroid-hormone receptor or nuclear receptor co-repressor 2 (NCOR2) is a large protein with multiple functional domains. It comprises the repression domain, Swi3, Ada2, NCoR1, and TFIIB (SANT)-like domain and a receptor interaction domain (RID). NCOR2 gene is mapped to human chromosome 12q24.31.
Specificity
Monoclonal Anti-NCOR2/SMRT recognizes human NCOR2/SMRT protein
Immunogen
the C-terminal region of GST-tagged SMRT protein
Application
Monoclonal Anti-NCOR2/SMRT antibody produced in mouse may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Silencing mediator for retinoid or thyroid-hormone receptor (SMRT) also known as SMAP270 or T3 receptor associating cofactor 1 (TRAC-1), serves as a transcription repressive co-regulatory factor for multiple pathways. A few to mention including inflammation, metabolism, circadian rhythms, developmental and homeostatic processes. Also, SMRT is essential for histone deacetylase 3 (HDAC3) activity that is required for chromatin structure and genome stability. SMRT protein is a part of NCOR/SMRT-mediated repression pathway together with the nuclear receptor corepressor 1 (NCOR1). They play pathophysiological roles in acute promyelocytic leukemia (APL), acute myelogenous leukemia (AML), multiple myeloma, Rett syndrome and deafness. NCoR2 is a target for microRNAs associated with glioblastoma.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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E Y Huang et al.
Genes & development, 14(1), 45-54 (2000-01-20)
Transcriptional repression mediated by corepressors N-CoR and SMRT is a critical function of nuclear hormone receptors, and is dysregulated in human myeloid leukemias. At the present time, these corepressors are thought to act exclusively through an mSin3/HDAC1 complex. Surprisingly, however
Adrienne Mottis et al.
Genes & development, 27(8), 819-835 (2013-05-01)
Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge chromatin-modifying enzymes and transcription factors. NCoR1
Amanda Shea et al.
Cancer medicine, 5(8), 1917-1946 (2016-06-11)
Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain, remaining incurable with a median survival time of only 15 months. In an effort to identify new targets for GBM diagnostics and therapeutics, recent studies have focused
Genomic characterization of spleens in patients with myelofibrosis.
Eran Zimran et al.
Haematologica, 103(10), e446-e449 (2018-05-12)
Pushpankur Ghoshal et al.
Cancer research, 69(10), 4380-4387 (2009-05-07)
Multiple myeloma (MM) is a clonal B-cell neoplasm that accounts for 10% of all malignant hematologic neoplasms and that affects terminally differentiated B cells (i.e., plasma cells). It is now well recognized that the cytokine interleukin-6 (IL-6) is a major
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