SAB4200674

Monoclonal Anti-PPIAL4 antibody produced in mouse

clone PP-8, purified from hybridoma cell culture

• Synonym(s): COAS-2, COAS2, PPIAL4, PPIAL4A, PPIAL4B, peptidylprolyl isomerase A (cyclophilin A)-like 4B
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: PP-8, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~18 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): immunoblotting: 2.5-5 μg/mL using whole extract of human HepG2 cells.
• isotype: IgG1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PPIAL4B(653505)

Description

General description

Monoclonal Anti-PPIAL4 (mouse IgG1 isotype) is derived from the hybridoma PP-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Peptidyl-Prolyl cis-trans isomerase A-like 4A/B/C (PPIAL4B) is a novel member of the cyclosporin-binding peptidyl-prolyl isomerase family.

The gene PPIAL4A (peptidylprolyl isomerase A like 4A) is mapped to human chromosome 1q21.

Specificity

Monoclonal Anti-PPIAL4 recognizes human PPIAL4B.

Immunogen

a recombinant protein of human PPIAL4B

Application

Monoclonal Anti-PPIAL4 antibody produced in mouse may be used in immunoblotting.

Biochem/physiol Actions

PPIAL4A (peptidylprolyl isomerase A like 4A) is a propyl isomerase which is required for folding of the proteins. In bone and soft tissue tumor, PPIAL4A exhibits high copy number.

Peptidyl-Prolyl cis-trans isomerase A-like 4A/B/C (PPIAL4B) is over-expressed almost exclusively in aggressive metastatic or chemotherapy-resistant tumors. Elevated levels of PPIAL4B are observed in bladder cancer, hepatocellular carcinomas, breast carcinomas and sarcomas.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable