SAB4200629

Anti-CNTNAP2 (C-terminal) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): 5430425M22Rik, AUTS15, CASPR2, CDFE, CG6827, CNTNAP2, CT21123, Cell recognition molecule Caspr2 (CASPR2), Dmel CG6827, Dnrx, KIAA0868, LOC559157, NRX, NRXN4, Nrx-IV, Nx IV, PTHSL1, contactin associated protein-like 2, l(3)68Ff, l(3)rsg23, mKIAA0868, rsg23
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• form: buffered aqueous solution
• species reactivity: rat, mouse
• concentration: ~1.0 mg/mL
• technique(s): immunoblotting: 1-2 μg/mL using whole extracts of rat brain; immunoprecipitation (IP): 2.5-5.0 μg using extracts of mouse brain
• UniProt accession no.: Q9CPW0
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... CNTNAP2(66797) ; rat ... Cntnap2(500105)

Description

General description

Contactin associated protein-like 2 (CNTNAP2) is a member of the contactin-associated protein family. It is co-localized with Shaker-like K⁺ channels in the juxtaparanodal region in myelinated axons. CNTNAP2 is mapped on the human chromosome at 7q35-q36.1.

Specificity

Anti-CNTNAP2 (C-terminal) recognizes mouse and rat CNTNAP2.

Immunogen

synthetic peptide corresponding to the C-terminal region of mouse CNTNAP2

Application

Anti-CNTNAP2 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Contactin associated protein-like 2 (CNTNAP2) mediates interactions between neurons and glia during nervous system development and is also involved in the localization of potassium channels within differentiating axons. Mutations in the CNTNAP2 gene is associated with autism spectrum disorder (ASD). CNTNAP2 gene mutations also lead to cortical dysplasia-focal epilepsy syndrome (CDFE) and Gilles de la Tourette syndrome.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at -20 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable